Why Metabolic Detox Is Not Just a Fad
by Deanna Minich, PhD
As you read through health magazines or blogs, you probably see all kinds of articles or ads promoting the next great miracle product: a detox or cleanse. The influx of products—many of which have no scientific evidence backing their promised efficacy—has led many to think that detox is just a scam or a fad. However, that is not the whole truth.
Although some of these products might be ineffectual, there are also many reputable items and programs out there that actually do work. It is these that will withstand the test of time and demonstrate that true metabolic detox is not merely a fad.
Not convinced? Read on and find out why you should give it a shot!
We live in a toxic world
The industrial, chemical, and technological revolutions greatly benefited us in many ways, but they have led to a highly toxic world. Environmental exposure to pollution, chemicals, and other toxins is linked to a variety of noncommunicable diseases,1 including cancer, asthma, neurodevelopment conditions, obesity, cardiovascular disease, diabetes, and neurodegenerative conditions like Alzheimer's disease.2
Everyone is exposed to a number of toxins through their water, food, air, personal care products, and other elements in the environment. These include:
- Heavy metals
- Pesticides and herbicides
- Flame retardants
- PCBs (polychlorinated biphenyls)
The human body can mitigate these toxins, but there comes a time where there is just too much, tapping out the body's own resources.
It requires support
Your body has its own detoxification process, which in the scientific and medical community is often referred to as biotransformation.4 There are three steps to this process: biotransformation, conjugation, and elimination.
During the first stage, toxic molecules, which might come from the outside world or from metabolites of your own body processes, get molecularly transformed into a different molecule. Sometimes it becomes less toxic, but many times, it actually becomes more toxic! Luckily, the next step mollifies it into a less toxic molecule. In this phase, the molecule combines with another molecule to create something that the body can eliminate. The third step is elimination, which in some discussions on detox is excluded but is just as important as the other two steps. Once your body has transformed the toxic elements into a benign molecule, it must be excreted through your urine, feces, or sweat.
All of these processes occur whether you are on a metabolic detox regimen or not, but they often need help! Each phase requires certain vitamins, minerals, antioxidants, and other nutrients. If you have more toxins, then you will need more of these nutrients to handle the increase in the processes while your body tries to remove them from your system.
Some people have genetic differences5 that alter their detoxification pathways. In some instances, it speeds up either stage one or stage two. In others, it slows a stage down. Certain foods, medications, and other factors also might impact the efficacy either positively or negatively. In these instances, you might also require additional support to handle the detoxification process.
If two stages are not in sync, problems might arise. If you churn out more toxic molecules from stage one without being able to handle stage two at the same rate, then all of a sudden you have a backup of potentially troublesome molecules in the body. Similarly, if you finish stage two but cannot eliminate the toxins, they might get recycled, causing issues.
Good detox programs provide you with the food, nutrients, and herbs that support your body's own natural detoxification system to ensure it works smoothly, in sync, and at the speed you need.
Nutrients needed for metabolic detoxification
You want to ensure that you have the nutrients necessary to support the biotransformation and elimination process to get rid of the toxins in your body. You can also incorporate foods known to support the process,6 such as green tea, curcumin, cruciferous vegetables like broccoli, and dandelion. Additionally, you want to support your liver, your kidneys, and your gut, the three systems most heavily involved in detoxification.
First and foremost, the process needs energy to undergo the different stages of detox! Phase one requires antioxidant support, since it typically releases a lot of free radicals. Nutrients to ensure you consume to support your phase one include:
- B vitamins, especially B2, B3, B6, B9, and B12
- Glutathione, the body's major antioxidant
- Protein, especially branched-chain amino acids
- Vitamins A, C, and E
- Coenzyme Q10
- Silymarin (found in milk thistle)
Many of the molecules needed for conjugation are amino acids, so protein is important to support phase two. Specific nutrients necessary for this phase include:
- B vitamins, especially B6, B9, and B12
- Antioxidants and phytonutrients
Don't forget about getting the toxic metabolites out of your body through supporting your elimination processes. This includes sweating, whether from exercise, saunas, or something else. You also want to ensure you are hydrated and consume plenty of fiber!
Creating a metabolic detox diet
Many of these nutrients are found in a generally healthy diet made up of primarily plant foods and whole foods. Thus, an essential step in providing your body with these nutrients is replacing calorie-dense foods with little to no nutrition, such as the highly processed foods rampant in the typical Western diet, with nutrient-dense foods, such as fruits, vegetables, whole grains, nuts and seeds, lean protein, and healthy fats. Furthermore, switching to an organic diet7 has been shown to significantly lower the level of pesticides in the body even in a short period of time.
To take it a step further, you want to incorporate a detox diet that emphasizes certain foods, nutrients, and herbs known to provide support for the pathways. A good detox diet not only provides you with the nutrients your body needs to process and eliminate the toxins you face every day, but it also should have the nutrients you need for all the other processes your body undertakes, as well as your daily activities!
Don't forget to mitigate your exposure to environmental toxins as much as possible through using air and water filters, consuming organic foods, limiting your plastic use, and more.
So is detox a fad? NO!
In the highly toxic environment in which most people live, our body requires support to do its natural practice of eliminating toxins. In fact, it is essential not just to do a metabolic detox or a cleanse as a one-off, but to adopt a detoxifying lifestyle that provides a defense against the toxins to which you will be inevitably exposed.
- Norman RE et al. Environmental exposures: an underrecognized contribution to noncommunicable diseases. Rev Environ Health. 2013;28(1):59-65.
- Moulton PV et al. Air pollution, oxidative stress, and Alzheimer's disease. J Environ Public Health. 2012;2012:472751.
- Fourth National Report on Human Exposure to Environmental Chemicals Updated Tables, January 2017, Volume One. https://www.cdc.gov/exposurereport/pdf/FourthReport_UpdatedTables_Volume1_Jan2017.pdf.
- Liska D et al. Detoxification and biotransformational imbalances. Explore (NY). 2006;2(2):122-140.
- Marinković N et al. Polymorphisms of genes involved in polycyclic aromatic hydrocarbons' biotransformation and atherosclerosis. Biochem Med (Zagreb). 2013;23(3):255-265.
- Hodges RE et al. Modulation of metabolic detoxification pathways using foods and food-derived components: a scientific review with clinical application. J Nutr Metab. 2015;2015:760689.
- Oates L et al. Reduction in urinary organophosphate pesticide metabolites in adults after a week-long organic diet. Environ Res. 2014;132:105-111.